Outside of Sirchester there is an NPC who states that he swam from the Kalos Region (from Pokémon X & Y) to the Galar Region. If what he says is true then this confirms that the two regions are in close proximity to each other just like their real-world European counterparts of the United Kingdom (Galar) and France (Kalos), which, in real life, are very close but separated by the English Channel.

There is a very rare chance that a Pokémon in the wild will come to the player's Pokémon camp while they are playing in it and ask to join the player's team. If the player selects the "Yes" option then not only will the Pokémon be able to join the camp but the Player will have also "caught" the Pokémon without battling it (it will go into one of the Player's Poke balls).

In the mission "Clean House", if you shoot the baby you'll get a screen saying "Children are non-combatants" and be taken back to the last checkpoint. If however you shoot the baby a third time, you'll get a screen saying "Are you serious?" and be dismissed back to the mission map screen.

Taking the camera inside of Dungeon Man on the Magicant stage will allow you to see Brickroad, who was the operator of the man-dungeon hybrid in Earthbound.

Within 10 months after its release, the Nintendo Switch sold more units than the Wii U sold during its entire life span. By comparison, the Switch sold 14.86 million units in the first 10 months of its release on March 3, 2017, while the Wii U sold only 12.5 million units from its launch on November 18, 2012 until it was discontinued on January 31, 2017.

The Super Mario Land 2 official strategy guide contained an interview with game's director and designer Hiroji Kiyotake. In the interview, Kiyotake stated that Wario's favorite food is crepes.

The game's director, Naoto Ohshima, stated on Twitter that Blinx was based on the fairy tale character 'Puss in Boots'.

In the prototype version of the game, Raidou is given an end card sequence, hinting that he would have been unlockable in the final version.

"Is this the end? ...
I looked down at my opponent who fell at my feet and muttered the thunder track. It's been a long time since you came out to be chasing a village like this or the one Kirigen Tenjinryu. Since then, the thunder road has only sought power for appetite. Fight against all the fighters, made his technique his own. I was asked to be a member of the tournament because I had a feeling that I might be able to meet the hunger for mosquitoes. However, it seems to be useless. The thunder road called a storm and disappeared into the fog..."

Bayman's codename "Gatsby" from the game's early development is based on the American novel The Great Gatsby.

The very first character developed for the game was a fighter codenamed "Kelly", who was originally cut from the final roster for being incomplete compared to later characters. However, since the team needed one more fighter, they decided to go back and develop a more complete version of Kelly. That character became the final version of Zack.

After defeating the game's final boss, by using debug controls and using the free camera mode during the game's cutscene, you can actually see Jak & Ashelin Praxis kissing onscreen, rather than cutting to Daxter. Often these scenes would not be fully animated, but the character expressions change where they would usually not be seen.

A game called Dead or Alive: Code Chronos was in development for the Xbox 360. The game would have been a prequel to the series and would relay the story of Ayane and Kasumi before the first tournament. However, the progress of Code Chronos came to a halt due to Itagaki's dispute with Tecmo. In 2010, the project was then confirmed canceled by the current head of Team Ninja, Yosuke Hayashi.

A promotional image advertising Dead Or Alive 4 featured an ad for Code Chronos in the bottom-right corner.

In the Carnivora area, in one of the buildings there is a corpse surrounded by a heavy amount of white substance while at a computer. This is a reference to the South Park episode 'Over Logging'. The character Randy after not being able to look at internet porn for so long, uses what was last of the internet resulting him to covered from head to toe with semen.

In an interview with game's producer, Koji Igarashi,found within the game's official Japanese strategy guide, he was asked why he set the game in Japan. He responded:

"Well, I know I keep saying that the protagonist of Aria of Sorrow, Soma Cruz is Japanese, but for the overseas version, we said he was a foreign exchange student living in Japan. That seemed like the best way for westerners to relate to the character, given that Castlevania is very popular in Japan and overseas. That’s why I asked the illustrator Aya Kojima to “draw him like a Japanese person who doesn’t look very Japanese.” And I’ve had people tell me he doesn’t look Japanese to them, so mission accomplished."

In Japan, the game was originally called 'Dracula 2', but the game's creator and director, Hitoshi Akamatsu, thought of the title 'Simon's Quest' for the game's release in Western regions.

The game's international box art show only Mario & Sonic, while the Japanese version also features Luigi, Bowser, Amy, Yoshi, Peach, Dr. Eggman, and Knuckles.

One of Lety's ambient dialogue is a reference to the science-fiction series Doctor Who. When talking to an NPC she might say "Soooo .... anyone check out my bag? It's very colorful, and kinda has a whole Doctor Who thing going on where it's bigger on the inside! Very video-gamey, the more I think about it ..." alluding to the the spaceship the TARDIS which is dimensionally transcendental, meaning it's bigger on the inside than on the outside.

In Crosstown, stars of the let's play web series Game Grumps, Arin Hanson and Ross O'Donovan, make a cameo where they can be seen together drawing on pads. Both Ross and Arin also voice characters in the game.

The game's world was originally called Orthodoxia, but this was later changed to Cvstodia.

The collectible 'Sternum of Vitas, the Performer' is a reference to the real-life actor, producer, writer and Did You Know Gaming? contributor Vitas Varnas. The description for the item reads, "Cvstodia remembers with admiration the name of Vitas Varnas. He inspired the lives of his people through his altruistic actions as well as his inspirational words."