In April of 2019, the game was banned in Nepal after the Nepal Metropolitan Crime Division filed a Public Interest Litigation with the Kathmandu District Court. The reason for the ban was due to parents and schools complaining about the game affecting their children's studies. Psychiatrists in the country also claimed that the game made more people aggressive due to the in-game violence, which influenced the authority's decision. All ISPs and mobile service providers were ordered by the Nepal Telecommunication Authority to block the game.

In the Egyptian-themed levels, there are hieroglyphs of black dogs on the wall that are speculated to represent Morgan T. Dog (now deceased), a pet mascot of Naughty Dog. N. Sane Trilogy kept this reference intact.

Sale of the game in Japan was halted in 2019 after actor and musician Pierre Taki, who voices the game's character Kyohei Hamura, had been arrested for illegal drug use. Taki admitted to violating Japan's drug laws after a urine test showed positive for cocaine use. SEGA said in a statement that all digital and retail sales of the game would halt until the truth was found, and also deleted all tweets mentioning the game from their Twitter account.

On the eastern side of the map, between Boston Common and Back Bay District, there is a door to an underground bar known as the Prost Bar. Prost, translated from German, means "cheers" and the area is a reference to the TV sitcom "Cheers" which ran from the early 80's to the early 90's.

The character Jam Kuehnemund's name is a possible reference to Jan Kuehnemund, the former lead guitarist of the rock band Vixen.

An anime re-telling of the game was produced titled Mario to Yoshi no Bouken Land (translated to Mario & Yoshi’s Adventure Land), and released exclusively in Japan in 1992 for the Bandai VHS system Terebikko. Using the fake phone device, players would interact with it when prompted to answer questions and press one of four colored buttons. The VHS animation ran for twenty-eight minutes.

In the international versions of the game, the Chameleon characters from the previous installment were changed to feature more realistic chameleon designs. However in the Japanese release, all of the chameleons retained their cute appearances as seen in the previous game. All images and objects found in the game which featured the chameleons also featured these changes to reflect the chameleon designs of that version.

A port of the game for the Nintendo 64 was in development but was canceled due to poor sales of the game Body Harvest. The port was in development for six months around the end of 1998 and was dropped before it was publicly announced.

The Dragon Ball Z: Collectible CD Picture Cards were a series of multimedia pocket CD-ROMs released exclusively in Australia in 2001 and were compatible with PC and Macintosh. Designed and produced by Streamedia Pty Ltd, there were 10 CDs to collect, each featuring a different character and were available randomly in packets and as a promotion given away with the purchase of Coca-Cola products. Each disc contained information on the respective character and each Dragon Ball Z saga up to the Cell Saga, information on merchandise and a "BattlePrint" activity mode. Despite saying "DBZ Set 1" on the packaging, no additional series were ever released.

A lot of Team Rose's levels end at a much earlier point than Team Sonic and Dark's. However, through the use of glitches, exploits, or cheats, it's possible to go past the goal ring with Team Rose and go to areas that are only accessible to the two other aforementioned teams. The same thing can also be done in some of Team Chaotix's levels as well.

Interestingly, the characters of both Team Rose and Chaotix have fully voiced and functioning dialogue for these normally inaccessible areas.

In the Mojave Desert stage, the second set of oil pumps on the side of the road obscure a billboard and is usually unreadable during a race. Stopping and reading the billboard will reveal the text:

"Sometimes, God takes MOMMIES
and PUPPIES away...
And sometimes...
Just sometimes...

I do"

Despite the game receiving a PAL version, this release was never available in Europe and only released in Australia.

Ports of the game for the GameCube and PlayStation 2 were planned to be released alongside the PC and Game Boy Advance releases intended for Spring 2003, however they were eventually canceled due to Asylum Entertainment, who were developing the PC, PlayStation 2 and GameCube versions, parting company with some staff who were working on them.

The game's story set-up in the Nintendo 64 and PC versions is that the wizard's accident is caused due to him mixing the wrong potions causing him to turn to stone, however in the PlayStation intro the incident is instead depicted as being deliberately brought about by the glove that becomes the game's villain, Cross-Stitch. The manual for the PlayStation release retains the incident as being an accident and not deliberate as seen in the other versions.

The Hasta La Vista Station title, tagline and mission text are all references to the Terminator franchise: The title is a phrase from the original 1984 film, the tagline "I know now why you ink..." is a reference to the line "I know now why you cry" from the 1991 sequel, the use of the word "terminate" for the mission description is unique to this mission (normally it is "defeat").

In the Octo Expansion, Stations Maverick, Goose, and Iceman are named after the nicknames of the characters from the film Top Gun. The taglines for these stations "Revvin' up your Inkjet...," "Listen to its howlin' roar...," and "Jet into the danger zone..." are references to the song "Danger Zone" by Kenny Loggins, which was used in the film.

The idea of not having "item boxes" in the game was based on "Sweet Home". The team wanted to remove it, so that it would feel a lot harder to play.

In the Octo Expansion, the many titles and taglines of stations contain references to music from the 80s-90s:
• Roll Out Station - "Rollout" by Ludacris.
• Fake Plastic Station - "Fake Plastic Trees" by Radiohead.
• Bounce with Me Station - "Can I Get A..." by Jay-Z.
• "Just go ahead now..." Spin Docto Station - "Two Princes" by Spin Doctors.
• "Just cruisin'..." Rad Ride Station - "Just Cruisin'" by Will Smith.
• "Blowin' up like it's all good." Notorious Station - "Juicy" by The Notorious B.I.G.
• "Bring da ruckus!" Phat Splatz Station - DJ Phat Beatz and "Bring da Ruckus" by the Wu-Tang Clan.
• " Step it up!" Breakdance Station - "Step It Up" by Stereo MC.
• "As 50 yellow balloons go by..." Pop Rock Station - "99 Red Balloons" by Nena.
• "Ya like to..." Move It Move It Station - "I Like to Move It" by the Outhere Brothers.
• "Stamp-collaborate and glisten!" Stamped-Up Station - "Ice Ice Baby" by Vanilla Ice.
• "Don't just stand there..." Bust 'n' Move Station - "Bust a Move" by Young MC
• "Round round round round..." Right Round Station - "You Spin Me Round (Like a Record)" by Dead or Alive.
• "Splat magic splat!" Labyrinth Station - "Magic Dance" by David Bowie.
• "Watch out now!" Ink & Watch Station - "Watch Out Now" by The Beatnuts.
• "Gettin' dizzy with it..." Don't Ralph Station - "Gettin' Jiggy wit It" by Will Smith.
• Swass 8-Ball Station - Sir Mix-a-Lot album, Swass.
• "Inkulators, mount up!" Squee-G Funk Station - "Regulate" by Warren G and his record label "G-Funk"
• "Take it easy..." Slow Ride Station - "Slow Ride" by Foghat.
• "Don't stop 'til you pop enough!" Pop Star Station - "Don't Stop 'Til You Get Enough" by Michael Jackson, who was known as "The King of Pop."
• "Who let the pods out?" Duh-Oh Station - "Who Let the Dogs Out?" by Baha Men.
• "Might as well..." Jump Station - "Jump" by Van Halen.
• "What's the dealio?" Cubular Station - "What the Dealio" by Missy Elliot.
• "Y'all bready for this?" Toastmaster Station - "Get Ready For This" by 2 Unlimited
• Ride with Me Station - "Ride wit Me" by Nelly.
• "Ink it real good!" Ink It Station - "Push It" by Salt-N-Pepa.
• "My my my my..." Can't Touch This Station - "U Can't Touch This" by MC Hammer.
• "Can't c me..." All Eyez Station - "Can't C Me" by Tupac Shakur from his album All Eyez on Me.
• "Ink-a-zig-ah..." Girl Power Station - "Wannabe" by the Spice Girls.
• "Do not miss your chance..." One-Shot Station - "Lose Yourself" by Eminem.
• "Watch your step!" Footloose Station - "Gettin' Jiggy wit It" by Will Smith.

The reason the Alien AI in the game is broken is due to a one letter spelling error in the game's .ini file. The line is written as

"ClassRemapping=PecanGame.PecanSeqAct_AttachXenoToTether -> PecanGame.PecanSeqAct_AttachPawnToTeather"

when it should read;

"ClassRemapping=PecanGame.PecanSeqAct_AttachXenoToTether -> PecanGame.PecanSeqAct_AttachPawnToTether"

Removing the letter A from this line fixes many of the issues with the game's AI.

At one point in development, it was planned for the Working Joe enemy to quote lines from William Shakespeare in a malevolent manner. However, it was ultimately decided it didn't fit with the tone of the game and the few recorded lines were cut from the game.