Jacky Bryant is likely based on the design of Super Saiyan Trunks from Dragon Ball Z, with game designer Seiichi Ishii stating in an interview that Jacky was inspired by a ‘Super Saiyan’ from Dragon Ball.

The character Lau Chan was inspired by Mercenary Tao, also known as Tao Pai Pai, from the original Dragon Ball manga and anime. Lau was even once named Tao Chan, which is speculated by fans to be a combination of Tao Pai Pai and Jackie Chan. This connection also extends to Lau Chan’s daughter, who would be named Pai Chan. Pai Chan was also based on an ocha tea commercial actress.

In the West Offices of the RPD Station there is a locker with the name JoJo on it. This is a reference to the manga and anime series JoJo's Bizarre Adventure and appeared in the original Resident Evil 2 as well.

The games working title was Legacy of Goku 2: Future Shock. The title was dropped mid-way through development. All three LoG games were meant to have subtitles.

The game was originally called Legacy of Goku 3: Buu's Fury, but the Legacy of Goku part was dropped by Atari for what appeared to be marketing reasons.

Using the Free Look tool included with the Gamecube emulator Dolphin, a rather grim Easter Egg can be found on the packaging box of the character Mr. Snuggles.

The message is flipped upside down and reads:

I'll hug you and kill you.

You'll never sleep again.

I'll kill your parents.

Sheik was planned to appear in Twilight Princess, but was cut from the game. This unused design was later used for Super Smash Bros. Brawl.

The attached artwork is from the Hyrule Historia.

A bizarre image of a turkey leg inside the EA Sports ring can be found in the original Playstation version's data. This also appears in the Madden 2002 to 2005 games.

The North American version contains only Landon Donovan on the front cover, while the European version, known as FIFA Football 2003, has Roberto Carlos, Ryan Giggs, and Edger Davids on it instead.

Rick Hunter, who played the Postal Dude in the previous two Postal games, dropped out from voicing him in the third installment. This was due to personal reasons at the time as Hunter was going through a "major" break-up with a girl. Despite the developers hoping to have him back, they cast Corey Cruise, who had provided voice work for other Postal content and was also good friends with Hunter.

In 2020, the game was removed from the digital distribution service Steam due to featuring "photos or videos of human actors." with a public notice stating that it was removed by the publisher which was untrue. Despite Valve allowing adult video games onto the service as of June of 2018, this apparently doesn't mean the inclusion of actual footage of real-actors in adult-oriented titles, though no mention of this is stated anywhere in the Steamworks Documentation.

Within the second level of the Clock Tower stage, there's a hidden exit which in the Japanese version when entered will feature a cameo by a Japanese personality accompanied with a secret message from them. If encountered on either easy or normal difficulty, idol Hiroko Nakayama will appear with a different message on each difficulty. When encountered on hard mode, Weekly Famitsu chief editor Hirokazu Hamamura will appear. Both personalities were hosts of the video game TV show Game Catalogue II which also mentioned the secret in the July 8, 1995 episode with behind the scenes footage shown in the July 22, 1995 episode.

A lot of error messages, sometimes vulgar, others hilarious, can be found in the PS2 version's data, including:

"Pad disconnected sometime in past...
duh? The fooking camera has fooked off!
Bad media type or no disk - PTOOIE!...
DVD drive is smoking crack!
Wot the hell? safety camera deleted!!!!"

The soundtrack became the first in video gaming history to become certified Platinum by the Recording Industry Association of America (RIAA), selling over 1,300,000 copies worldwide.

The design for Kula Diamond was aided by the input of the female staff to properly depict a 14-year-old girl with "appropriately girlish" gestures.

The second page of the The Strand newspaper, issue December 2nd, 1894, has a drawing of Inspector Jacques Clouseau from the Pink Panther series. Specifically, the image is taken from the theatrical poster for the 1982 film Trail of the Pink Panther.

In the scene of Sherlock and Watson on the train departing from Switzerland, a young boy named Hercule approaches Sherlock to help solve his puzzle box and the boy's mother appearing named Madame Poirot. This is a reference to the fictional detective Hercule Poirot by author Agatha Christie, alluding to the young boy being the character.

On the left hand of the NPC Champagne, a tattoo can be seen of the logo for Frogwares, the game's developer.

The game meant to introduce Whip into the Ikari Team. However, due to Leona's introduction in the same team, the developers waited until The King of Fighters '99 to add her to the cast.

It is possible to pull up both Link's and Spawn's character profiles in the PlayStation 2 version of the game via mods or hacking, despite neither character appearing in this version of the game.