According to environment artist Ted Anderson in an interview with YouTuber KIMI TALKZ, Retro Studios was apparently hesitant on working with Nintendo to create the game:

If the player attempts to leave town, an alternate ending will play depicting a boy pleading the Man With No Name to "come back, Shane," to which he responds by shooting him for getting his name wrong before leaving. This cutscene parodies the ending of the 1953 western film Shane, right down to the boy's design.

Some of the game's cutscenes are poorly drawn renditions of scenes from the Clint Eastwood film For a Few Dollars More.

•"Do you have the right time old man?" - Game Version / Original Film Version (mock-up)
•Train Scene - Game Version / Original Film Version

In addition, the game's title is a play on Clint Eastwood's character "The Man with No Name" from the same film.

In the Shivering Isles DLC, trying to speak to one of the Apostles in The Howling Halls will display "I HAVE NO GREETING".

Despite the game portraying heavy usage of violence, blood, and sexual content, the game is still considered to be family-friendly based on the Commodore CDTV version's box cover.

The game was ported to the Wii as Cruis'n with any references to The Fast and the Furious being removed entirely due to Midway losing the license to the series during the game's development.

The game was originally an arcade game titled The Fast and the Furious, which was soon ported to the Wii with any references to The Fast and the Furious being removed entirely due to Midway losing the license to the series during the game's development.

Among the files included in the Gigaleak, a massive 2020 content leak of internal data from Nintendo, are models associated with Dōbutsu no Mori depicting three human characters not seen in the final game: two redcoat soldiers, one tall and one short, and a middle-aged woman in an apron. These characters appear to be early versions of Copper, Booker, and Joan, respectively, which is corroborated by the fact that the woman's filename is "oba," with Joan's sleeping animation being labeled "Sleeping_Obaba" in the files for Dōbutsu no Mori.

All of this appears to indicate that special characters were originally intended to be human before being changed to unique animals later in development; in the final game, the only humans that appear on-screen are the player characters. Copper and Booker would later reincorporate the scrapped redcoat motif in Animal Crossing: Wild World and Animal Crossing: City Folk.

Originally, the cutscene that plays after Spoiler:the Phantom Thieves believe Ryuji to be dead after the destruction of Shindo's palace was going to feature extra lines of dialogue not present in the final game, as well as a dialogue tree for Joker, the player's character. Additionally, there are unused animations in the game's files Spoiler:showing the Phantom Thieves beating up Ryuji. In the final game, the scene cuts to black.

Within the Xbox 360 and PlayStation 3's map files, there is a partially unused texture containing an early design for Nimbus.

Originally, instead of controlling a Wind Warrior in co-op mode, the player would have taken control of Nimbus. A partially unused transformation animation (which was re-purposed into a flying transition animation for the final game) and a stunned animation for Nimbus can be found in the game's files.

Urien's ending in Street Fighter III: 3rd Strike was going to be somewhat different, as seen in early storyboards.

The storyboards show that the building of the secret society was going to be a modern skyscraper in the middle of a city while the final game shows a building similar to the Tower of Babel in the desert.

Additionally, the ending featured a giant sphere containing the brains of past Illuminati leaders. This was replaced in the final game with tubes containing the bodies.

The Koopa Troopa shell bouncing between the pipes of the Wii Koopa Cape’s starting gate is a reference to a Koopa Troopa’s behavior when Mario/Luigi steps on them a second time.

JoJo's Bizarre Adventure: Heritage for the Future was named after Stardust Crusaders' (the story arc in which this game is based on) original name during serialization in Weekly Shōnen Jump, Part 3 Jotaro Kujo: Heritage for the Future.

In the 34th entry of the Anime News Network series Jason Thompson's House of 1000 Manga, Jason Thompson stated that Capcom USA was disatisfied with how Jojo's Venture was doing in arcades at the time, to the point that he was told by a Capcom USA employee that they wouldn't release the game on home consoles "unless CAPCOM Japan forced them to".

As of Version 1.04.01, there is a glitch in which Malenia will regain health while attacking a player character that is in their long death animation. This in turn can make the fight more difficult in multiplayer if her aggro does not change from a killed player until their health bar is completely off screen.

Like Mario & Luigi: Dream Team, Paper Jam also had "Bros." added to its name in the UK release, again with no official reason given.

However, given that there are already two trademarks for "PaperJam" as well as a brand of toys that were sold in the UK under the name "Paper Jamz", it is more than likely Nintendo repeated the easier road by adding "Bros."

In the UK and Australia, the game is changed to add the "Bros." at the end of the title.

While no official reason was given, the trademark for the name "Dream Team" was filed in the UK in 2010, and was still valid until the games release. It's possible Nintendo added the "Bros." at the end to avoid any legal issues with the trademark.

According to composer Grant Kirkhope, the DK Rap was written as a joke song that ended up being interpreted by audiences as a serious attempt at writing hip-hop. Consequently, he expressed confusion at the tongue-in-cheek cult following the song picked up decades later, noting that "bizarrely, this became its own thing now."

Leona's Desperation Move "Rebel Spark" is likely inspired by the Revolcane attack from the 1989 television series, Kamen Rider Black RX