The Game Boy Camera had several images of Pokemon, and released almost 4 months earlier than Pokemon Red and Blue in North America, making the Game Boy Camera North America's Pokemon debut.

The unlockable end credits of the Game Boy Camera samples the Twinkle Elementary School theme music from Mother, better known as the Your Name, Please? theme in its internationally released sequel, EarthBound. The director of the Game Boy Camera, Hirokazu "Hip" Tanaka, had previously composed the soundtracks for both games.

In the Japanese version, there's a print icon that looks like a syringe. The image was replaced with a "Game Boy Printer" icon in the International version due to possible drug references.

The photo on Neil Young's "Silver & Gold" album cover was taken with a Game Boy Camera.

Selecting "Run" from the menu will bring up one of three drawn on faces, bearing the caption "Who are you running from?" Nobody knows why.

These faces are also shown without the caption when the system encounters an error such as attempting to print without having the printer connected.

In the View menu, clicking on the Credits/Staff Roll planet will show a clip of an unknown Japanese man dancing instead of showing the game's credits. It's not known who this dancing man is due to the compressed image quality making his face unrecognizable. While it is popularly believed that the identity of the dancing man is Shigeru Miyamoto, this is unlikely as he did not work on the Game Boy Camera and does not appear in the game's credits. The game's real end credits can be unlocked by Spoiler:beating Run! Run! Run! in under 22 seconds. During the start of the real end credits, you can view the clip of the dancing man again by pressing B.

At the time of its release, the Game Boy Camera was the world's smallest digital camera.