At the time of its release, the Game Boy Camera was the world's smallest digital camera.

In the View menu, clicking on the Credits/Staff Roll planet will show a clip of an unknown Japanese man dancing instead of showing the game's credits. It's not known who this dancing man is due to the compressed image quality making his face unrecognizable. While it is popularly believed that the identity of the dancing man is Shigeru Miyamoto, this is unlikely as he did not work on the Game Boy Camera and does not appear in the game's credits. The game's real end credits can be unlocked by Spoiler:beating Run! Run! Run! in under 22 seconds. During the start of the real end credits, you can view the clip of the dancing man again by pressing B.

Selecting "Run" from the menu will bring up one of three drawn on faces, bearing the caption "Who are you running from?" Nobody knows why.

These faces are also shown without the caption when the system encounters an error such as attempting to print without having the printer connected.

The photo on Neil Young's "Silver & Gold" album cover was taken with a Game Boy Camera.

In the Japanese version, there's a print icon that looks like a syringe. The image was replaced with a "Game Boy Printer" icon in the International version due to possible drug references.

The unlockable end credits of the Game Boy Camera samples the Twinkle Elementary School theme music from Mother, better known as the Your Name, Please? theme in its internationally released sequel, EarthBound. The director of the Game Boy Camera, Hirokazu "Hip" Tanaka, had previously composed the soundtracks for both games.

The Game Boy Camera had several images of Pokemon, and released almost 4 months earlier than Pokemon Red and Blue in North America, making the Game Boy Camera North America's Pokemon debut.

Among the files included in the Gigaleak, a large-scale leak of internal server data from Nintendo in 2020, is a build for a Hello Kitty-themed version of the Game Boy Camera. This version features numerous differences compared to the standard version of the peripheral. In addition to reskinning assets to include various Sanrio characters, the Hello Kitty version also features more extensive overhauls such as a total reworking of the menu (namely to make previously hidden features overtly visible to the player) and various new modes and minigames.

The Hello Kitty Game Boy Camera appeared to have been scrapped fairly late into its development. In addition to how fleshed out it is even when compared with the simpler released The Legend of Zelda edition, the Nintendo 64DD features a unique header for it, POCKETCAMERA_SN, in code designed to check if a Game Boy Camera is plugged in. Additionally, although the device was shelved, at least two songs from it were reused in the Mobile Trainer, a Japan-only peripheral which allowed online multiplayer on select Game Boy Color games via a cell phone connection.