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There is a Shotgun in the game called 'Dog'. In the game's code, its file name is "Thre Dog", and its special weapons effect reads, "Because one barrel ain't enough, and two is too few." This is likely a reference to the character "Three Dog" from Fallout 3, who says "Three Dog, because one dog ain't enough and two is too low, it's Three Dog!"
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In Sanctuary, there is a chance that an NPC will say "I used to be a Vault Hunter like you, until I took a bullet to the knee." This is a reference to the infamous "I took an arrow in the knee" meme from The Elder Scrolls V: Skyrim.
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There is a skill for the Mechromancer called "20% Cooler" This is a Reference to the TV Series "My Little Pony: Friendship is Magic" where the character "Rainbow Dash" says "It needs to be about 20% Cooler".
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There is a side mission in the Tiny Tina DLC called "Lost Souls." In the mission, the player helps an undead warrior by collecting souls at camp fires, just like in Dark Souls.
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The mission title "Hungry like the Skag" refers to a Duran Duran song, Hungry Like the Wolf, as Skags are wolf/dog-like creatures in the game.
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In the Hammerlock DLC there is a side quest "The Rack Dahlia Murder". The mission title is a reference to the unsolved 1947 Black Dahlia murder that occurred in California.
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There is a unique relic in the game called the "Deputy's Badge" which is awarded for finishing the mission "The Showdown". Part of its description reads "Who the hell shot me?", a reference to the Bob Marley song "I Shot The Sheriff", the chorus for which begins with "I shot the sheriff, but I did not shoot the deputy."
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In the mission Assassinate the Assassins, the Assassins are called "Wot", "Reeth", "Rouf" and "Oney". "Wot", "Reeth" and "Rouf" are anagrams of "Two", "Three" and "Four" while "Oney" is just "one" with a "y" on the end.
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The skin "Vault Dweller" for the Siren is a reference to the outfits worn by the members of the vaults from the Fallout series. It follows its color pattern with blue body and yellow highlights.
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In the Caustic Caverns, across the acid water, there is a small island with a Knight named Solitaire sitting on a ledge in front of a bonfire. White phantoms are also sitting in front of the bonfire. This is a reference to Dark Souls, with Solitaire being a reference to the knight Solaire of Astora.
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While fighting enemies as Axton, he may say "And YOU get a bullet, and YOU get a bullet! EVERYONE gets a bullet!" - a reference to Oprah Winfrey's energetic nature and giving audience members gifts.
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There is an enemy called "King Mong", an homage to King Kong, that can be found in the game.
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There is a challenge called "It's Not Easy Looting Green" which is a reference to Kermit the Frog's song "It's Not Easy Being Green".
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There is a challenge in the 4th DLC called "FUSROHDIE". This is a reference to Skyrim's 'FUS RO DAH' dragon shout.
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The mission "The Pretty Good Train Robbery" is a reference to the 1903 film, The Great Train Robbery.
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There are several references to the Predator franchise made throughout the game. The skill "Sexual Tyrannosaurs" and "You ugly mother..." are lines said in Predator by Blain Cooper. The achievement/trophy "Unseen Predator" is a reference to the Predators cloaking device. One of the loading screen tips says "if Bleeds we can kill it etc." which is also a reference to the original film.
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The challenge titled "Crouching Tiger, Hidden Assault Rifle" is a reference to the movie Crouching Tiger, Hidden Dragon.
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There is an enemy called Rakkman located in a cave in the fridge, a homage to the "Batman" series. He may drop a weapon called the Gunerang, a reference to Batman's Batarang. In the second play through, his name is changed to Rakkman Forever, a reference to the film Batman Forever.
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In the Tiny Tina DLC there is a side quest called "Winter is a Bloody Business.", which contains several references to Game of Thrones. King Jeffery is a reference to King Joffery, and the throne is similar to the show's Iron Throne, but made of guns instead of swords.
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The mission "Won't Get Fooled Again" is a reference to the song of the same name by 'The Who' which is used as the theme tune of television series CSI: Miami. The mission requires the player to solve a murder and upon completion, Marshall Friedman will say a melodramatic one-liner like the main protagonist of the show 'Horatio Caine' does.
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