At the end of each level, the game shows a congratulations screen that is purposely misspelled as "conglaturation!"

This is a reference to the NES game Ghostbusters, and the infamous ending screen which misspells congratulations the same way.

The Boss of "Dungeons & Dickholes" is based on a creature from the movie "The Giant Claw".

The same creature was also feature in another FreakZone game, MANOS: The Hands of Fate, as a Boss named "Battleship Bird" from End Credits.

The Game Over Screen of AVGN Adventures is based on a Game Over Screen from Friday the 13th on the NES, reading "You and your friends are dead. Game Over". During the review for the game the Nerd suggests making it even more severe, and suggests;
"You're dead. Your friends are dead. Your family's dead. Your fucking pets are being skinned alive. Your mom's a fucking whore. You suck at life. The whole world hates you. You're going to Hell. Live with it. Game Over."

The design of the poop spitting monsters found in the Thy Farts Consumed level are based on the Cacodemons from the Doom series.

The moon from The Legend of Zelda: Majora's Mask appears in the background of the Assholevania level.

The beginning of the Boss Battle theme sounds extremely similar to a segment of the track: "Porky Means Business!" from Earthbound.

The final boss, Spoiler:"Fred Fucks" is based on Spoiler:"Fred Fuchs" whose name was in the credits in the video game Spoiler:"Bram Stoker's Dracula" based on the movie of the same name. In the Angry Video Game Nerd Spoiler:Dracula episode, the Nerd jokingly pronounced the word Spoiler:"Fuchs" as "Fucks".

The game's final stage, "Laughing Joking Numbnuts", is based on ##LJN##'s logo, and the name that the Angry Video Game Nerd has adopted for the company.

The level, "Beat It & Eat It," was originally made with 16-bit style graphics before it made the switch to Atari graphics.

The level Boo! Haunted House is named after the Nerd's nickname for the Nightmare on Elm Street NES game.

The "beginner's trap" the Nerd made up in his Super Pitfall review appears in the Dungeons and Dickholes level, appropriately down the first ladder in the level.

BlackFlag (one of the developers for the game) said that the Guitar Guy (Kyle Justin), looks like a skeleton in Adventures because he was originally going to look like himself and have dialogue. Later in development, Kyle decided not to have his likeness in the game. His appearance was changed into a skeleton and his dialogue was replaced. The new character is a reference to the Angry Video Game Nerd's Ikari Wars review, where it's revealed that Kyle died, but is revived later in the episode.

The original sprite of Kyle can still be seen on the game's box art.

Arin Hanson, also known by his alias EgoRaptor, can be found hiding atop a cloud in the level "Blizzard of Balls". When talking to him, he'll say "Don't be a Grump, take these!" which the Nerd will say "Thanks, EgoRaptor. Now I'm not so Grump!". The dialogue is a reference to the web series Game Grumps which Arin co-hosts.

The level "Future Fuckballs 2010" is based on the game Street Fighter 2010 which the Angry Video Game Nerd had previously reviewed on his show.