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Once you defeat the CAT-209 boss, it will say a message in binary code. Once translated it says "FUCKYOUNERD".
The Final Stage "Final Tower 1: Virtual Insanity" is based on the Virtual Boy, which was reviewed in episode 42 of the Angry Video Game Nerd.
After losing half of his health during his boss battle, General Dark Onward will transform into a scorpion. This is a parody of Darth Vader turning into a scorpion in Star Wars for the Famicom, a game which was previously reviewed by AVGN.