There is a random encounter in Fallout called "Unusual Call box" in which the player will stumble upon a blue, British police box. This is a reference to "Doctor Who", specifically its TARDIS.

If the player's character has less than 4 intelligence, they will be unable to talk to anyone properly. Having low intelligence unlocks a new set of dialogues for the player, which mostly consists of grunts/noises. It also unlocks new responses from certain NPCs who recognize the player's disability.

The original concept art for Deathclaws had them as mammals with fur, but due to technical limitations of the rendering software, the hair was removed.

There were plans to include a race of mutated raccoons called the S'Lanter, who had built a small community known as the Burrows. The S'Lanter and their home village ended up not making it into the game, for reasons such as not fitting in well in the Fallout world and also for time constraints, as the time needed to build and then animate the various versions of them was simply too much. The only remaining in-game mention of them is a Holodisk about FEV experiments located in The Glow.

There is an NPC found in The Hub named Deputy Kenny. If Deputy Kenny is killed, the Display Monitor in the lower left corner will display the message "Oh my God! They killed Kenny! Those bastards!" This is a reference to the cartoon series South Park.

Inside many buildings in Fallout and Fallout 2 there are posters of artwork from American Rock band, TOOL'S first album "Undertow" released in 1993. The artwork on the poster is of the bands vocalist, Maynard James Keenan.

Typing "boom" during the credits will have Tim Cain's head appear on screen and explode.

Tim Cain was the lead programmer for the game, and one of the original members of the game's design team.

There is a random encounter called the "Giant Footprint", in which the player will stumble upon a giant, dinosaur-like footprint with a dead body in the middle, holding a Stealth Boy, making it seem like whatever stepped on him never saw them. The encounter is likely a reference to the giant lizard-monster Godzilla.

Loxley, the head of the Thieves' Guild located at the Hub, gets his name from the English tale of Robin Hood, more specifically the Robin Hood:Prince of Thieves film starring Kevin Costner. The name "Loxley" comes from the village and alleged birthplace of Robin Hood, and Loxley's own fake/fading English accent is likely based of Kevin Costner's constantly-disappearing accent in the film.

The pre-made character "Albert Cole" may have gotten his name from the film A Boy and His Dog. Blood, the psychic-powered dog, would often call the boy "Albert", even though that was not his real name. The same film was shown at A Post-Apocalyptic Film Festival, which was held to promote the release of Fallout 3.

When installing the game on a modern PC using icons larger than 32x32 pixels, the game will use an image of Tim Cain's head as its icon in place of the original Vault Boy.
Tim Cain is the original creator, and was the lead programmer for Fallout.

A number of promotional items were produced as bonus items, or to help advertise the release of the game, these include;
•A tin cup (actually made of aluminum) with the Fallout logo.
•A ball point pen designed to look like a stimpak, which contained a purple liquid.
•Postcards
•T-shirts depicting a Brotherhood of Steel member and the phrase "Everything Else is Dead or Dying."

The music that is played on the world map of Fallout and Fallout 2, "Moribund World", was heavily influenced by the track "window sill" by Aphex Twin.

If you let the Master's Army destroy Necropolis, a ghoul refugee who survived the invasion can be found hiding behind a bookcase with dialogue talking about the invasion, while also mentioning that the attacking super mutants had "some steam trucks". These steam trucks are the only working mechanically propelled vehicles mentioned in the game, and are only mentioned in this Fallout game.

In the eighth installment of the Fallout Bible, Fallout 2 developer Chris Avellone revealed that steam trucks were planned for Fallout, but they were only mentioned in passing for "art reasons and gameplay reasons" and that it may have been an "ugly-looking vehicle".