In the arcade version, there are armed enemies which drop fire arms when they die, which can later be used by the player. These enemies along with the usable weapons were removed from the SNES version.

If the player lands a lethal blown with Captain Commando's flamethrower or similar fire attacks the enemy will burn until they turn into ash. This does not happen in the SNES version, where the burned enemies stay on the ground before dissapearing.

Some of the enemies in the game have Ride Armors which the player can also control. This feature wasn't available in the SNES version, with the Ride Armors being completely removed.

The enemy known as Mardia attacks by spitting green slime to the player. Because the attack makes it look like she's vomiting, this was changed in the SNES version where she throws bombs to the player instead.

At the beginning of the level you can see two enemies smoking cigarettes while squatting. This does not happen in the SNES version.

Most enemies melt away after recieving a lethal hit from Mack. This does not happen in the SNES version and instead they simply drop to the ground.

Most of the enemies can be dissected if they recieve a lethal hit from Ginzu. This does not happen in the SNES version.

Blood and pink smoke (the latter happens when Mack hits the enemy) where removed from the SNES version.

Ginzu's profile in the arcade version mentions he's capable of dissecting his enemies while Mack's says he can melt them. These details were removed from the SNES version.

The outfits of the female enemies Carol and Brenda show more skin in the arcade version, whereas in the SNES version they are more covered up.

Some of the characters have different names across regions.

•The playable characters Sho, Jennety, and Hoover were renamed to Ginzu the Ninja, Mack the Knife, and Baby Head respectively.

•The 7th stage boss Blood was changed to Boots. This change was exclusive to the SNES version.

•The final boss Genocide was changed to Scumocide.