In the Kanto region, all of the towns are named after colors, the only exception being Pallet Town, which was named after the word "palette," or a range of colors used by an artist or in a picture.

There is an exploit that, when used correctly, allows your Ditto to trick a wild Pokemon into using Transform.

This is only possible with the Pokemon Pidgey, Pidgeotto, Spearow, or Fearow as they are the only wild Pokemon who know Mirror Move. If your Ditto uses Transform on a wild Pokemon who uses Mirror Move in the same turn, The wild Pokemon transforms into Ditto. The game also registers the wild Pokemon as Ditto.

In the Pewter Museum of Science in Pewter City there is an attraction featuring a space shuttle. In Red & Blue, the plaque accompanying the space shuttle model reads "Space Shuttle Columbia"; however, in the Generation III remakes the plaque simply reads "Space Shuttle". This is probably due to the fact that on February 1, 2003, the real Space Shuttle Columbia disintegrated upon re-entry during its 28th mission, killing all seven crew members. The reference to Space Shuttle Columbia was kept in the Japanese version of the Generation III games.

In Pokémon Red, Blue, and Yellow, as well as their remakes FireRed and LeafGreen, a truck was placed in the S.S. Anne's port. The truck seems to serve no purpose. Its presence in the remakes could be a reference to the original rumors that Mew could be found under the truck.

Concept art shows a shop owner with a Pokemon on a shelf. This may indicate that Pokemon were originally going to be sold in shops.

According to a journal entry in the game, Mewtwo's birthday is February 6th.

During development, a type called "Bird" was going to be in the game, but was later changed to flying. This is still in the game's code, with Missingno. being a bird/normal type.

Ninetails was inspired by a powerful, fire-breathing fox with nine tails from Japanese mythology.

The game contains the now infamous line: "Hi! I like shorts! They're comfy and easy to wear!" The line became a meme among the Pokemon community, and was referenced in Pokemon Black 2 and White 2.

When you encounter your rival in Pokemon Tower, he will ask you why you're in the tower to begin with because you don't have any dead Pokemon to mourn over. This implies that he has lost a Pokemon and has come to pay homage to it or lay it to rest. Furthermore, his Raticate from the previous battle on the S.S. Anne is replaced by an Exeggcute, Growlithe, or Gyrados, depending on the starter Pokemon you chose. This seems to imply that his Raticate somehow died between the battles against him on the S.S. Anne and in Pokemon Tower; common fan speculation states that the Raticate died from wounds received from the battle on the S.S. Anne.

During the Professor Oak lecture at the beginning of the game, a Nidorino will be shown as an example of a Pokemon. However, the cry that plays belongs to a Nidorina.

In Copycat's bedroom is a SNES with a game featuring Mario with a bucket on his head. This is a reference to the Japan-exclusive game Mario & Wario, another Nintendo game developed by Game Freak.

On Route 10 in Pokémon Red & Blue, Picnicker Carol gives a description of a chunky, pink Pokémon with a floral pattern. This description perfectly matches the Pokémon Munna, from Pokémon Black & White released twelve years later.

The three legendary birds (Articuno, Zapdos, and Moltres) are puns on elements, as well as numbers in the Spanish language. Articuno is Arctic (ice) and uno (one), Zapdos is Zap (electricity) and dos (two), and Moltres is Molten (fire) and tres (three). This is also the order that they appear in the National Pokédex.

Mew was secretly added at the very end of development and was initially not intended to appear in the game. However, due to a glitch, Mew started to appear seemingly naturally (i.e. without GameShark and the like) in some peoples' games.

Mew was the first Pokemon name to be trademarked, even before the name "Pocket Monsters".
Mew was trademarked 1990, while Pocket Monsters was trademarked in 1995.

Dratini's sprite as found in Red, Blue, and Green (both the original Japanese release and the updated International release with different sprites) Versions has stripes on its belly. These stripes were removed in Yellow Version and have not reappeared since.

The original Red and Green Versions were supposed to have a female trainer along with the male trainers, Red and Blue. She was most likely removed due to hardware restrictions, but is still seen on the official strategy guide and artwork. The character was used as the character 'Green' in the comic and 'Leaf' in the remake, FireRed and LeafGreen.

Charizard was unable to learn Fly in Red & Blue. This was changed in Yellow which also made it possible to get a Charizard with Fly in Red & Blue via trading.

There were originally going to be 190 Pokemon instead of 151; 39 of them were later moved to Pokemon Gold and Silver. By checking the game's code, you can see the orders in which the Pokemon were entered into the game, Rhydon being first and ending with Victreebel. Since Ken Sugimori, the designer of the Pokemon, confirmed that Rhydon was the first Pokemon ever designed, it can also be inferred that the Pokemon were put into the game in the order in which they were originally intended to appear in the Pokedex. The ordering also proves that all 190 Pokemon were conceived before the original games' release.