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Originally, Dr. Mario was planned to be an original intellectual property, known as Virus, featuring numerous differences from the final game. Even before the name change though, a doctor resembling Mario appeared in 1-Player Game mode.
The Cutting Room Floor articles:
https://tcrf.net/Proto:Dr._Mario_(NES)/Virus_1989_%26_1990
https://tcrf.net/Proto:Dr._Mario_(NES)/April_27,_1990_Prototype
https://tcrf.net/Proto:Dr._Mario_(NES)/Virus_1989_%26_1990
https://tcrf.net/Proto:Dr._Mario_(NES)/April_27,_1990_Prototype
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