In the PlayStation version of Innocent Sin, if you wait on the Load screen for 4 minutes and 15 seconds, a short acoustic version of the game's ending theme "Next to You" will play.

In The PlayStation magazine interview with the game's art designer Kazuma Kaneko, he was asked about how the game's title 'Sin' (Persona 2: Innocent Sin) and the main theme of 'rumors' tied together in the game's story. He responded:

"My definition of “rumor” is when a person makes a judgment based on their own preconceptions and prejudices, and then recklessly disseminates that to the wider world. When that stuff circulates and circulates, you know… it could eventually become a sin. Even though we never intentionally think we’re committing a sin, I bet in our everyday lives this kind of thing happens a lot. A careless comment you make could have a major impact on someone else’s life. Those ideas are intertwined with the story of Persona 2."

On the PSP, "Hitler's" name was replaced with "Fuhrer" and his appearance was altered, the Swastika symbols in the background were also removed.

The Demon Painter is modeled after the series artist Kazuma Kaneko.

Persona 2 was split into two games, Innocent Sin and Eternal Punishment. However, America and Europe only got Eternal Punishment. There are some theories as to why Innocent Sin was not released over seas, but the real reason is unknown and the updated PSP remake of both games did make it to America and Europe.