Kirby Tilt 'n' Tumble 2 was a sequel game that was being developed for the Nintendo GameCube and was originally scheduled for release in May 2002. It was first shown at Nintendo Space World 2001 and was demonstrated by Shigeru Miyamoto. The game was supposed to demonstrate how the Game Boy Advance could be used with the GameCube as a controller, using a special cartridge in the Game Boy Advance to detect tilting. Miyamoto also made a passing mention that players could write "programs", such as minigames, onto this cartridge. A second demo of the game was shown off at E3 2002; Kirby was removed as the player character, and the game was reworked and retitled as "Roll-o-Rama", named after a minigame in the original Kirby Tilt 'n' Tumble. According to Miyamoto at DICE 2003, development on the game had slowed down by that February to meet the demands of other projects, and the game was never heard from again afterwards.

In the original Japanese release, the Hamburger food featured in the American version was an onigiri (a riceball).

The title screen was redesigned during the translation of the Japanese version for the game's U.S. release.

Two unused Kirby sprites can be found in the game's data which were meant to be uncovered in the position test in the options.

All of the minigames had their names changed in the English release. They include:
• Kirby's Balloon was changed to Kirby's Burst-A-Balloon
• Dance The Kirby was changed to Do the Kirby
• Kirby's FuriFuri Chicken Race was changed to Kirby's Chicken Race
• Kirby's Multi Ball was changed to Kirby's Roll-O-Rama. Also, the Kirby on the bottom right was moved slightly and the Blue Kirby's shadow was extended a little

An issue of Nintendo Power magazine revealed that the names of the first two levels are "Big Sky Country" and "Tilt 'n' Tunnel", even though none of the levels are ever named during gameplay.

The game cartridge for Kirby Tilt 'n' Tumble is unique among Game Boy Color cartridges, as it has a notch in its top right corner which usually only appears on original Game Boy games. This notch enabled original Game Boy cartridges to fit inside the system's cartridge slot. Other GBC exclusive titles lack this notch and will therefore not fit inside of an original Game Boy. A Game Boy will also not turn on when GBC games are forced into the slot.

Kirby Tilt 'n' Tumble, however, displays the following message when played in a Game Boy:



It's possible that the game cartridges for Kirby Tilt 'n' Tumble were re-purposed from another, non-GBC exclusive game. Kirby Tilt 'n' Tumble is only Game Boy Color exclusive game with this feature.