In October 2021, Chinese voice actor Li Yuantao was accused of having multiple affairs and using his fame to manipulate multiple girls into having sexual relationships with him, some of whom were reported to be minors. Because of these accusations, several popular mobile titles announced that they would be severing ties with him, such as the dating simulator Light and Day, the survival horror game Identity V, and the action RPG Genshin Impact. The latter game responded by removing the character Fischi from the game's rate up system for one year, as Yuantao voiced Fischi's raven companion Oz.

On February 7th, 2023, Tighnari's English voice actor Elliot Gindi announced on Twitter that he would be taking a break from his online activity to seek therapy, claiming that the "influx of fans and fame" he gained from his work in the game "really messed [him] up". The following day, two moderators for Gindi's fan Discord servers posted to Twitter alleged evidence of offenses that Gindi had conducted in private, ranging from emotional abuse, blackmail, sexism, and having sexual relations with underage fans, with other users also coming forward to accuse Gindi of further acts. Shortly after these documents were posted, Gindi posted a Twitlonger tweet confirming that most of the allegations were true, although he denied the allegations involving underage fans. On February 16th, the game's developer HoYoverse released an official statement revealing that Gindi would no longer be voicing Tighnari, with the official reason being a "breach of contract". They also confirmed that the character would be recast at a later date, and on April 11th, they revealed he would be replaced by American actor Zachary Gordon.

The Legend of Zelda: Breath of the Wild is held in high regard by the development team, and is cited as one of the main inspirations for Genshin Impact.

"In a post that our team circulated to players last year, we mentioned that The Legend of Zelda: Breath of the Wild was one of our inspirations for creating Genshin Impact as an open-world action RPG. That said, it is important to note that once you actually pick up the game, you will find the experience of Genshin Impact to be very different from that of The Legend of Zelda: Breath of the Wild."