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In Chapter 1, the faces of the other marker test subjects on the computer in the observation room, are actually members of the UI Development team.
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In Chapter 1 in the area with the first shop, there is a working scale that shows Isaac's weight at 195 pounds. After he equips his Engineering Suit, he weighs 255 pounds.
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In Chapter 5, if Isaac lets Spoiler: the Tormenter kill him in space, a hand will float through space, as an homage to the original Dead Space cover.
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