The interior of Jowee's House features a poster of the game Lock's Quest, which was also developed by 5th Cell and published by THQ, and a stuffed doll based on the character Bluebit from that game.

The game's ending was changed when released in the Drawn to Life Collection.

The original ending Spoiler:featured Mike and Heather holding dolls of Mari and Jowee before they are both in a car crash, resulting in both of their parents dying. Heather is severely injured, and Mike is sent into a coma. This suggests that the game took place in Mike's mind while he was in a coma. In the end, Mike wakes up.

In the rerelease, the ending was changed so that Spoiler:Mike simply falls from a tree and becomes unconscious while his sister looks over him. He then wakes up, and looks over to his Mari and Jowee dolls.

There are a number of unused sprites in the game's files that seem to show other character heads on Mike's body. This would suggest that Mike's body was used as a placeholder sprite for other characters, or perhaps even as a base when redrawing new characters. These unused sprites only have worried and cheering animations.

The Creator in the Drawn to Life series seems to represent the Christian God, as one of the Creator's quotes is clearly based on a quote from Genesis 1:3. The Book of Life is a book given to the Raposa civilization by the Creator, so it's comparable to the Christian Bible. Wilfre, the villain of Drawn to Life, was a power-hungry character who turned against the Creator and became evil. He attempts to destroy the Book of Life many times, and he leads others down evil paths. He seems to represent Satan.

At the end it is revealed that Spoiler:all the game's events occurred inside a coma experienced by a boy named Mike. In an early cutscene, Heather tells Mari and Jowee to "Kemi-Kewa", which when unscrambled says "Wake Mike".