The German language version of the game removed all references to the word "Nazis" from the game's dialogue:

• In "Chapter 3 - A Surprising Find", the word "Nazis" is replaced with "crew" when Nate and Sully came across a U-857 (German U-boat).
• At the end of "Chapter 17 - The Heart of the Vault", references to Nazis are simply replaced with the word "they".

Sir Francis Drake's motto "Greatness from small beginnings." was a mistranslation, the actual motto of Francis Drake is "Thus, from small beginnings, Great Things Come."

At the end of Uncharted, Spoiler: Nate and Elena are about to kiss but are interrupted by Sully. This might be a reference to Jak and Daxter, in which Jak and Keira get interrupted by Daxter before they kiss in every game. Both series were developed by Naughty Dog.

Victor Sullivan's private seaplane, Hog Wild, is a reference to a level found in Crash Bandicoot.