After their release, series creators Matt Stone and Trey Parker were very publicly critical of the quality of Acclaim's South Park games. According to All Games Network co-founder Scot Rubin (who employed a former playtester for Acclaim as a cameraman), Stone and Parker were said to have worked closely with Acclaim on the first South Park game, but lost full creative control over the following two games as Acclaim became more restrictive. Upon ending their partnership with Acclaim, they became very protective of the South Park license, shutting down any potential pitches until the 2009 game South Park Let's Go Tower Defense Play! Reflecting on Acclaim losing the license in 2001, Stone had this to say:

The characters Mrs Crabtree, Chickenlover and a clown were originally intended to be playable characters and not just level obstacles. They can become playable by hex-editing the game's files, and have their own character menu portraits and sound files. There is one unfinished character in the game's files, Fat Abbot (a parody of the Bill Cosby character Fat Albert), who was cut from the game early into development possibly to avoid copyright issues.

Despite only being not playable in the Nintendo 64 version, the characters Ms Cartman, Mrs Broflovski, and Scuzzlebutt, and extra skins for characters, can be found in the game's files.

Mephesto's vehicle is the DeLorean time machine from "Back to the Future".