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The scene where Elliot Edward gets attacked by zombies is censored in the Japanese release. In the international version he loses his lower body and guts and entrails are visible, whereas in the Japanese release he still has his legs intact. Even in the CERO Z version of the game (the version with the highest possible rating) his death is still censored.
Contributed by ZpaceJ0ck0
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In the West Offices of the RPD Station there is a locker with the name JoJo on it. This is a reference to the manga and anime series JoJo's Bizarre Adventure and appeared in the original Resident Evil 2 as well.
Contributed by domino22
In the West Offices of the RPD Station there is a desk with a nameplate that says "Rita Phillips." This is a reference to Resident Evil Outbreak: File 2, where Rita was one of the last survivors who managed to escape the police station before Leon and Claire's arrival.
Contributed by domino22
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The license plate on Claire's motorcycle, "J2198", is a nod to Resident Evil 2's original release date, January 21st 1998.
Contributed by Mass Distraction