The intro to Sephiroth's theme, "One-Winged Angel", was inspired by the intro to the song "Purple Haze" by the Jimi Hendrix Experience.

Cloud's Buster Sword was originally a lot smaller and thinner with only one Materia slot. Tetsuya Nomura's original vision of the Buster Sword was unrefined steel, and he referred to it as "the Giant Kitchen Knife".

In the Ghost Square section of the Gold Saucer there is a pumpkin with green eyes in the corner of the room to the left of reception at the inn. Interacting with this pumpkin will cause it to laugh. This laugh is in fact a slightly slower version of the iconic laugh of Kefka Palazzo, the villain from Final Fantasy VI.

On January 17, 2022, the Italian Senate hosted a Zoom meeting about the Transparent Public Service. Just when Nobel Prize-winning physicist Giorgio Parisi was about to be introduced, a user named Alex Spence "zoombombed" the meeting with at least 30 seconds of a CG pornographic video featuring Tifa Lockhart that was originally made by Patreon user JuicyNeko. The news spread mere days after the incident, and Tifa became the subject of memes that associated her with Italy, including being considered an Italian video game mascot that’s on par with Mario.