In late 2023, Yandere Simulator creator YandereDev was accused of grooming a minor after the person in particular revealed several screenshots and audio recordings between them, prompting some of the game's developers and voice actors (including Michaela Laws, the voice of main character Ayano Aishi) to leave the project. On top of this, three games that had previously crossed over with Yandere Simulator severed ties with the game:

• Glowstick Entertainment ended all future sales of Dark Deception: Monsters & Mortals' crossover DLC with Yandere Simulator, as well as officially cancelling Ayano's Lovesick Labyrinth (a planned crossover between Yandere Simulator and Dark Deception, previously shelved).
• Sad Panda Studios announced that they would be updating Crush Crush in order to replace Ayano (who had been added as a guest character) with an original character named Ayeka.
• xDNA replaced the guest characters Ayano and Info-chan with reskinned original characters named Patti and Emily respectively.