After their release, series creators Matt Stone and Trey Parker were very publicly critical of the quality of Acclaim's South Park games. According to All Games Network co-founder Scot Rubin (who employed a former playtester for Acclaim as a cameraman), Stone and Parker were said to have worked closely with Acclaim on the first South Park game, but lost full creative control over the following two games as Acclaim became more restrictive. Upon ending their partnership with Acclaim, they became very protective of the South Park license, shutting down any potential pitches until the 2009 game South Park Let's Go Tower Defense Play! Reflecting on Acclaim losing the license in 2001, Stone had this to say:

The Toy Store has a secret room that appears to be Chef's shack.

A direct sequel had been announced by Acclaim's CEO, Greg Fischbach, and was intended to be released sometime in early 2000. However the game was never released and any further details about it never surfaced.

A Game Boy Color version of the game was at one point being developed, however it was supposedly canceled because the show's creators Trey Parker and Matt Stone didn't think it was right for the platform because children were its main demographic. Only a single screenshot was released to the public in Nintendo Power magazine issue 114.

It's possible that Acclaim reused the game for "Maya the Bee" in Europe and "Mary Kate & Ashley" in the US as both share a similar HUD to the South Park game.

A prototype version of the game was later dumped onto the Internet in 2018.