At the Seacroft Hospital in Leeds, England, physiotherapists have incorporated Wii Fit into their sessions with patients who have lost a limb and are learning to use a lower prosthetic limb. Senior physiotherapist Lynn Hirst states that many times patients have trouble "getting their weight through the prosthetic limb." However, with the aid of the balance board, Wii Fit allows patients to see "where they are taking their weight." Hirst stated that the Wii Fit therapy has been "absolutely fantastic" for all of her patients, and hopes that other Hospitals will follow suit with similar programs.

There are a large number of Mario sprites from the original Super Mario Bros. game hidden throughout Wuhu Island. These can be found during the running game.