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The Kerotans from the PS2 version are replaced with Yoshi dolls. If shot, they make the "Yoshi!" cry. If the player calls up Para-Medic, she will start talking about how popular Yoshi has gotten in the Soviet Union. This is strange as the game takes place in the 1960's, at lest 20 years before Super Mario World was released.
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If you have the 3D on, when you go into the first person view shots, they'll be in 3D. However, after Spoiler:Snake gets his eye shot out, first person view shots that look through Snake's eyes aren't in 3D. This is because he lost his right eye and has no depth perception, thus players cannot see in 3D.
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