If the player saves their game while in the Groznyj Grad jail cell after the torture sequence, Para-Medic will talk with Snake about the movie Dracula. If this save game is loaded, Snake will have a nightmare about a vampire, which is represented as a playable demo sequence of "Guy Savage", a cancelled Konami game.

In Metal Gear Solid 3: Snake Eater, the Cobra Unit member "The Fear" uses a crossbow in battle and coats his bolts in the venom of the Brazilian wandering spider. Snake is hit with a bolt in a cutscene and The Fear describes the effects of the venom. However, one effect wasn't described by The Fear and wasn't displayed in the game at all. As well as causing intense pain, the venom has similar properties to Viagra, giving the victim an erection.