In the final part of the game when playing with Ellen, she says "I'm an engineer, not a brain surgeon." This is thought to be a reference to Dr. McCoy from Star Trek who would often say "I'm a doctor, not a ____" . Harlan Elisson, one of the game's designers, also sold scripts to many television shows. One of them was Star Trek.
Harlan Ellison who made the novel "I have no mouth, and I must scream" also worked on this game. He was one of the designers, and voiced "AM" the super computer.
There are a few deleted scenes that never made it into the final game. Two of them are Gorrister feeding a live heart to a dog and Benny eating an infant child to survive.
In the French and German releases of the game, the character of Nimdok and his chapter as a whole was removed. The chapter was remove because it was based around a Nazi camp. The removal of the Nimdok chapter made the "best" ending unachievable.