There is a continuity error between the second episode of the video game "Blood of the Cybermen" and the television episode "The Pandorica Opens". On both occasions, Amy Pond doesn't recognise the Cybermen, even though the latter is set chronologically after, albeit the video game was published later. Amy also encountered them in the two video games "Doctor Who: Return to Earth" and "Doctor Who: The Mazes of Time", both also released after "The Pandorica Opens" but set prior. It's assumed by fans that this could be due to the cracks in time altering Amy's memories.

In the Guinness World Records 2012 Gamer's Edition book, Doctor Who: The Adventure Games was recognized as the "First Downloadable Stealth Games Based on a TV Show".

The game's development was partly funded by the BBC with UK television license tax fee money which was why the game was made available free to download only in the United Kingdom.

In the episode, "The Gunpowder Plot", while playing as Amy, inspecting either the Well or the Tyburn Tree in the Town will cause a "Silent" from Series 6 to appear by the object after the player turns away. When approached, it will provide some Earth history relevant to the object.

In the Episode: "The City of the Daleks", Older-style Daleks can be seen wrecked in the background of Kaalann.

One of the ideas suggested by the show's executive producer, Steven Moffat, for a Dalek story was about being miniaturized and put inside a Dalek. However, Moffat decided instead to keep the idea for a future television episode. The idea was used for the 2014 episode "Into the Dalek".