Prior to getting British rock musician David Bowie to compose the game's soundtrack, director David Cage had also considered commissioning Icelandic art pop singer Björk, Massive Attack, and Archive.

Designer Phillip Campbell stated in an interview with Edge Online that Quantic Dream had at one point intended to feature character animations based on the "signature moves" of David Bowie, who composed the game's soundtrack and voiced Boz and the Dreamers. However, when Bowie stated that he didn't have any signature moves, he brought in his choreographer, Edouard Locke, who was then motion-captured performing Bowie-esque techniques.

Omikron: The Nomad Soul was the first video game to feature acts by a real-world entertainer (in this case, David Bowie as the in-game band the Dreamers); while established musicians have composed soundtracks for other video games before Omikron, not until then had a game included an original performance.

In an interview with Edge.com, director David Cage stated that the main reason he was able to lead the game's development was because he insisted on paying the team.

David Bowie, who composed music for the game, included its lyrical songs on his 1999 studio album 'hours...' The album was the first to be officially available via the internet, with Bowie creating his own ISP and website to host the download.