While the game is considered non-canon, Kyle Travers was incorporated into the Street Fighter continuity via the Shadaloo Combat Research Institute's (a site dedicated to Street Fighter V) Character Reference section. Initially, he was only mentioned in Cody's profile (the English version of which claimed Kyle had yet to appear in a game, though this was not part of the original Japanese version, instead simply indicating he was Cody's brother), but eventually received a profile of his own. Notably, the Japanese version of his profile listed his girlfriend Vanessa Sims as one of his likes, implying she may be canon as well. However, this was changed in the English version of his profile, claiming he merely liked women.

Within the game, there are Final Fight arcade machines in any store that sells food. Smashing the arcade game will produce a Mike Haggar sound effect from the first Final Fight.

Cammy from the Street Fighter series makes a cameo in the game as an opponent in an optional pit fight.

Sodom and Poison were originally supposed to be in Final Fight: Streetwise. Art of the pair was featured in the comic that came with pre-orders of the game, but for some reason both characters were removed before the game's release.