The second trailer for Team Fortress 2 shows gameplay footage of each class, except for the Medic. However, the Medic does make two appearances in the video; once at 1:47, on the left, and once again at 1:50, he can be seen behind a wall.

The trailer also shows many sound and weapon changes. Some of these include the Scout using a weapon called the Nailgun, which was replaced by the Scattergun, and the Demoman can be seen throwing an pack of Dynamite, which was later replaced by his Stickybombs. Every class, including the Pyro, uses generic scream sounds for taking damage and dying, including the infamous Wilhelm scream.