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While the game was originally not supposed to be a co-op experience, Chris still had a partner to go with him to Africa and Sheva still existed in the game. Chris' original partner was Barry Burton, and Sheva was going to be a part of local militia fighting against the Bio Organic Weapons.
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Parts of Resident Evil 5's Beta were later used in Resident Evil 6. Mainly, the underground ruins, with parts being under water, Gigante-like giants assaulting a town while you had to protect another character trying to help, and a boss battle fought on a train where you had to run from car to car while fighting it. The monster itself (Irving) was also very similar to Birkin's final form.
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At the end of the game, Spoiler:Wesker falls into a volcano and is blown up by a pair of RPG-7 rockets. According to Producer Masachika Kawata, this is really the death of Wesker. "Even if you want Albert Wesker to come back, there is no chance he's coming back from that."
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Shinji Mikami, the creator of Resident Evil, didn't play RE5 until 2011, a whole two years after the game's release. This is because he didn't like the idea that someone else had made the game.
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At the very start of Chapter 1-1, if you let Chris and Sheva stand idly in the opening spawn area for about 30 seconds after the first chunk of dialogue finishes, a secret conversation can be triggered where Chris talks to Sheva about the impacts of American capitalism.
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