According to a 1999 Nice Games magazine interview with game's director Hideo Kojima, he was asked if the game was originally released for the PC-9821 computer, knowing that it had a very long development cycle:

"Yeah, that was crazy. It was progressing pretty well at first, and by 1990 I had all the storyboarding done—I did it all myself, you see. But thanks to a department transfer at Konami, and the PC Engine port of Snatcher, for awhile I didn’t have much time to work on it. So then when we were working on the PC-9821 version, by that point there was already talk about the next-gen hardware, and that’s how it ended up getting ported to the 3DO, Playstation, and Saturn."
Contributed by ProtoSnake
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The breast bouncing animations were toned down in the Playstation version, and the number of times the player can grab characters breasts was limited. According to the Playstation 20th anniversary Famitsu interview, the reason for this was because of a dispute between Hideo Kojima and SIE'S CEO Shuhei Yoshida, the latter believing that the feature was excessive.
Contributed by ZpaceJ0ck0
The visual designs of the co-protagonists Jonathan Ingram and Ed Brown are based on actors Mel Gibson and Danny Glover's roles as Martin Riggs and Roger Murtaugh from the Lethal Weapon series.
Contributed by ZpaceJ0ck0