When Kizaru uses his Ama no Iwato, he is shown charging energy in his hands. However, in his sprite, he is actually charging and shooting energy from his foot.

Garp is usually shown without his dog mask, but if the party leader is a Straw Hat member, he will be shown wearing the mask.

When Duval is chosen as a support character, he appears as he did before Sanji used Parage Shot on him. However, if Sanji is the party leader, his portrait and sprite will change to his handsome face.

By effect of being a sprite-based game, some characters have their trademark features mirrored when they look to the left (i.e. Crocodile's hook changes to his right hand, etc.). The two exceptions are Zoro, whose swords are always on his left hip, and Sanji, whose left eye is always covered by his hair.

Blackbeard has a alternative level 3 special attack, using the Gura Gura no Mi abilities. This is done by entering a specific password and having Whitebeard and two Blackbeard Pirates members as support characters.

The European release of the game did not retain the opening song from the Japanese release, "We Are" by Hiroshi Kitadani.

Before the game's title "One Piece: Gigant Battle!" was chosen, the game was announced under the name "One Piece: Project Jet".