The character Spoiler:Henry Cooldown returning from the first two No More Heroes games was redesigned by The 25th Ward: The Silver Case and Flower, Sun, and Rain illustrator Takashi Miyamoto.
The character Spoiler:Destroyman (returning from the first two No More Heroes games) was redesigned by freelance artist Skan Srisuwan of Studio HIVE.
The character Spoiler:Kimmy Love from No More Heroes 2: Desperate Struggle was redesigned by Okami and Bayonetta character designer Mari Shimazaki.
The character Kamui Uehara Spoiler:(from Grasshopper Manufacture's visual novel The 25th Ward: The Silver Case) was redesigned by "Goodnight Punpun" mangaka Inio Asano.
The character Native Dancer was designed by Borderlands series art director Scott Kester.
