In an special message made to celebrate the release of the game on Switch, director Goichi Suda stated that the game was originally called No More Heroes III FINAL BOUT - All Out Galactic War!. However they felt the title was too long, and so they ended up "taking a hint from the Rocky series" and shorten the title to just No More Heroes III.

The scene that comes after Spoiler:the Destroyman fight is a parody of the training scene from the film "Rocky III".

In the Rank 3 fight with Sonic Juice, the RPG Travis talks about hating is most likely Final Fantasy VII.

•The song before the fight is very similar Final Fantasy's "Prologue" theme, while the battle music seems to be a parody of Final Fantasy's battle music.
•The game is mentioned as being beloved by "everyone and their mom."
•Travis mentions he wouldn't play it even if they remade it.
•The style and layouts the menus match Final Fantasy.
•Ifrit, Bahamut, and Knights of the Round are all referenced in the Summons.

Goichi Suda has stated in an interview that they had originally developed the entire map as a playable area, but due to processing issues they had to close off large areas of it. He would state that if they ever released DLC for the game, he would like to add these areas back to the game.

Director Goichi Suda has stated in an interview that they had originally planned to have 7 playable characters in the game early in development. This would have included Travis Touchdown, Shinobu Jacobs, Bad Girl, Native Dancer, Notorious, Kamui Uehara, and Midori Midorikawa.

Only Travis Touchdown was playable in the final release. Suda stated that if they were to ever release DLC for the game, Shinobu would be his first pick as a playable character.

The final battle between Travis Touchdown and Spoiler:Damon Riccitiello is a parody of the Super Smash Bros. series.

Director Goichi Suda stated in an interview that the idea for the fight being a "total rip-off" of Super Smash Bros. was originally a joke. However once they actually developing it, he felt this may end up becoming a problem because it felt "really, really close to the actual game" and had decided to change the idea. However, representatives from Nintendo and even Masahiro Sakurai himself liked the idea and told him to keep it in the game.

The character Spoiler:Henry Cooldown returning from the first two No More Heroes games was redesigned by The 25th Ward: The Silver Case and Flower, Sun, and Rain illustrator Takashi Miyamoto.

The character Spoiler:Destroyman (returning from the first two No More Heroes games) was redesigned by freelance artist Skan Srisuwan of Studio HIVE.

The character Spoiler:Kimmy Love from No More Heroes 2: Desperate Struggle was redesigned by Okami and Bayonetta character designer Mari Shimazaki.

The character Kamui Uehara Spoiler:(from Grasshopper Manufacture's visual novel The 25th Ward: The Silver Case) was redesigned by "Goodnight Punpun" mangaka Inio Asano.

The character Native Dancer was designed by Borderlands series art director Scott Kester.