Tara Platt, the voice of Vert/Green Heart, was the only voice actress to not reprise her previous role for this game due her unavailability at the time of recording. Her replacement voice actress, Carrie Keranen, has also been the voice of Rom since Hyperdimension Neptunia mk2.

During the early stages of development, the character Uzume/Orange Heart wasn't planned to appear at all. At the time, Idea Factory was finishing development on Fairy Fencer F: Advent Dark Force, and feedback on the early stages of Megadimension Neptunia VII strongly suggested the addition of a new goddess in order to "bring more depth and complexity to the story".