The third tint of Nova's Dominion Ghost skin depicts Kerrigan before she was infested by the Zerg in StarCraft II.

When clicked on enough, Jaina will make a number of references. These include:

• "Azarath Metrion Zinthos", a reference to Teen Titans, and the words Raven says when casting a spell.
• The story of Rapunzel, where a young girl is trapped and raised inside a tower.
• Lyrics from the song "Do You Believe in Magic" by The Lovin' Spoonful.
• Lyrics from the song "I Put a Spell on You" by Screamin' Jay Hawkins.
• Referencing Disney's Frozen with the line "By the way, if you're holding on for a Frozen reference just let it go."

When clicked on enough, Rexxar will make a number of references. These include:

• Quoting Duran Duran's "Hungry like the Wolf".
• Making a joke about hunters in World of Warcraft taking undeserved loot.
• Continuing his animal pun joke from Warcraft 3.
• Showing frustration over people thinking he looks like Batman.
• Referencing Wheaties breakfast cereal by using their old "Breakfast of Champions" catchphrase.
• Playing Hearthstone, where he is a character for the hunter class.

Valla's name comes from the short story Hatred and Discipline, by Micky Neilson.

Palette 2 for Lt. Morales's default skin is based on the Alliance from Warcraft.
Her master skin's second palette appears to be based on the Varia suit from the Metroid series, and her master skin's third palette appears to be based off of Arcee from Transformers.

Artanis's purifier skin palette 2 and 3 appear to be based off of Evangelion series mechs, Unit-02 and Unit-01 respectively.

Falstad's Buccaneer skin appears to be based off of the Hearthstone card Skycap'n Kragg, as the description provided to Kragg in The Grand Tournament trailer also describes Buccaneer Falstad.

Sgt. Hammer replaced Edmund Duke and Horace Warfield from previous builds as the Siege Tank hero.

When recording dialogue for a character, the voice actors gave three different versions of each line.

The Chinese version of Stitches has his bones and gore covered with a purple polka-dotted fabric to avoid scaring children.

The game's cinematic trailer recycled models from other Blizzard property cinematics. The most striking difference is with Diablo, who's depiction in-game is based on his design from Diablo 2, while the trailer's depiction comes from Diablo 3.