There was originally an NCR super mutant ranger named Chauncey stationed at Station Foxtrot. he was included in early builds of the game, but ultimately cut prior to release.

The Feral Ghoul Roamer has an error when loaded into editing software. While this doesn't cause conflicts in the game itself, the model attempts to draw from a model labeled "mmm_ghoulvariant_v1.nif". This is one of the feral ghoul variants that appeared in the Fallout 3 mod Mart's Mutant Mod, suggesting that Obsidian Entertainment had experimented with it while developing new features for the game.

Obsidian's Scott Everts attributes some of the performance issues and simplifcation present in the game to the fact it wasn't a PC exclusive.

During an interview with Variety Fair, Todd Howard revealed that the 2024 live-action "Fallout" TV series was considered canon to the games, having wanted to tell an original story within the game's world rather than adapt any of the previous games. However, when the show came out, this led to complaints from fans accusing the show of retconning the events of Fallout: New Vegas. Specifically, the sixth episode "The Trap" featured a shot of a blackboard seemingly depicting the fall of Shady Sands (the capital of the New California Republic) as taking place in the year 2277. Fallout: New Vegas takes place in the year 2281, yet Shady Sands is stated to still exist in the game without any mention of a fall (although the city cannot be visited in-game). Emil Pagliarulo, a design director for Bethesda, would try to assure fans on Twitter that Fallout: New Vegas is still considered canon, claiming to being overprotective of the series' lore and going as far as to post a timeline of the Fallout series. While the timeline not only featured both Fallout: New Vegas, the TV series, and also confirmed that Fallout Tactics: Brotherhood of Steel is considered canon to the series, it did not address the timeline inconsistency brought about by the blackboard scene in the show. This reportedly led some fans to accuse Bethesda of holding a grudge against Obsidian Entertainment for making what many fans consider to be the best Fallout game and using the show as a way to spite them. However, it's worth noting that there are three other possible explanations for the inconsistency:

• Whoever wrote "2277" was misinformed due to the post-apocalyptic setting forcing many to rely on guesswork for event dates.
• It could be a simple mistake in writing for a series with large amounts of lore to it.
• It could be a reference to the "Lonesome Road" DLC expansion for New Vegas, where the player is given the option to nuke the NCR, though there is no confirmation that this ending is canon.

Howard would later defend the TV series and insist the game is still canon in an interview with IGN, claiming he had an emotional reaction when the TV series writers brought up the idea of bombing Shady Sands (which he also clarified was not a nuclear bombing) and carefully talked through the decision with them. When asked specifically about the 2277/2281 inconsistency, his response was that they were "threading [the needle] tighter there" to make it land in the TV series, move the Fallout series forward, and insisted that the fall of Shady Sands took place just after the events of the game. He reiterated that Bethesda was careful about sticking to the series timeline, admitting that there "might be a little bit of confusion at some places" and claimed that what was most important to them was what was happening in the time period of the TV series.