During the level Landed in Prison where Deadpool has to go save Rogue, the white textbox (who is later revealed to be Spoiler:Madcap in the comics) and yellow text box have this exchange:


At the time of the game's release, Rogue lost her ability to fly. Not only is it poking fun at established canon, but indirectly references X-Treme X-Men Volume 1, Issue #13. In this issue, during a fight with the villain Vargas, he stabs Rogue, and this causes her to lose her superpowers, including flight.