The title "Caladrius" was lifted from a legendary bird prominent in medieval European and Roman mythology that was thought to be a divine messenger of God. Caladrius would appear before those who were ill, and if there was a chance for recovery, it would fly away, carrying the illness with it. In a 2013 interview with the game's director Hitoshi Hoshino published in Shooting Gameside #7, he compared the design of the character ships to the bird's appearance, and added, "the title conveys that question: will there be any salvation or not?"