In the PAL box art, there is blood dripping of the knife and the man's hands. However, this was removed in the NTSC-U version.

In Tyler's bedroom, there is a desk with a figure on it. When examined, Tyler will say, "This is a figurine of Sox, a character from my favorite videogame." The figure is of Sox the Robot from Quantic Dream's first game, Omikron: The Nomad Soul.

The original title of the game was called Fahrenheit, and was used by most regions. In order to avoid relation with the movie Fahrenheit 9/11, the North American and Canadian releases changed the name to Indigo Prophecy.