The Sega Genesis had backwards compatibility with the Sega Master System if used in conjunction with the Sega Power Base Converter. The Sega Power Base Converter will not work with the Sega Genesis Model 3, Sega Nomad, or Sega 32X Add-on. The only Master System Games that aren't fully compatible with the Power Base Converter are F-16 Fighting Falcon and Alien 3. There are also several games that only work with the Master System Controller plugged in. These are:

• Alien Syndrome
• Bomber Raid
• Great Volleyball
• Montezuma's Revenge
• Penguin Land
• Shanghai
• Tennis Ace
• Where in the World is Carmen Sandiego?
• Wonder Boy in Monster Land