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Siren: Blood Curse was envisioned as a reimagining of the original Siren, with numerous alterations to its structure and content. In regards to this, director and co-writer Keiichiro Toyama stated the following:
"Siren Blood Curse is not a sequel or a standard remake of the other games. Suppose the events of the original SIREN were real, in that case Siren Blood Curse would be like a "movie based on a true story", adapting and dramatizing the original. While some of the key events bear resemblance to those in the first SIREN, the characters and the background are completely different."
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