Ryuu ga Gotoku Kenzan! allows you to briefly play as certain bosses in the series like Majima Gorohachi and Ito Ittosai in certain battle scenarios. This would mark the first time the Yakuza series would allow you to play as a character besides the main protagonist.

Two of Kiryu’s Bucket List memories in Like a Dragon: Infinite Wealth with the shared title "Dreams of a Past Life" have Kiryu reminisce on dreams he had where he was the historical figures Miyamoto Musashi and Sakamoto Ryoma. This references two games thought to be non-canonical spin-offs: Ryuu ga Gotoku Kenzan! and Like a Dragon: Ishin!, and suggests them to have actually been Kiryu’s dreams the whole time. This is also notable as Ryuu ga Gotoku Kenzan! has yet to receive an English release.