Two of the characters in the game, gun shop owner Robert Kendo, and police officer Marvin Branagh, originally had much larger parts in Resident Evil 1.5, with Robert Kendo (Originally named "John") helping Elza Walker out and Marvin accompanying Leon and Ada throughout his story. At one point in 1.5, it appears that Marvin, rather than Sherry in the final game, is infected with a virus and the player has to get him a cure.

In the final game, both die fairly early on, and the player even has to kill a zombified Marvin in their character's "A" scenario.