In an interview with competitive Super Smash Bros. player Hungrybox, the developers of Nickelodeon All-Star Brawl claimed that the game would feature cross-play in a future update. Cross-play was eventually finished for the game, but was not able to be released due to Nintendo's strict guidelines on cross-play. On March 3, 2023, the game was released on the Epic Games Store, and cross-play between PC and Switch was accidentally added without announcement, but was removed shortly after, though cross-play between Epic Games and Steam players would continue to exist in the game.

Cross-play would eventually be included in the base game of Nickelodeon All-Star Brawl 2 for all consoles and generations.