The Wild Villains, an original group of villains created for the game, are all based on characters from writer Kohei Horikoshi's previous manga, Oumagadoki Zoo:

• Curator is based on Isana, the main antagonist of the "Vs. Aquarium" arc.
• Zookeeper is based on Hana Aoi, the main deuteragonist of the series, with elements from Shiina, the main protagonist.
• Bearhead is based on Shikuma, the main antagonist of the "Vs. Circus" arc.