Charles Martinet provided all the voice work for the game.

In prerelease photos and trailers, Little Mac still had his original NES Punch Out design. It is unknown why or when it was changed.

Many of the original Punch-Out!! and Super Punch-Out!! cabinets were converted in to "Play Choose 10" cabinets, as they had the same design. Nintendo even sold conversion kits to help arcade operators. Because of this, finding an original intact cabinet of either game is very rare.