The game contains multiple references to previous games in the series. Most notably when Claire tells Moira a gun is "more reliable than any person" (quoting Steve from Code: Veronica), Barry saying he is the master of unlocking (referencing a scene from the original game) and Claire saying she was almost "a Claire sandwich" (referencing Barry from the first game). Also worth noting is that just like in her previous appearance, Claire wakes up abducted on a prison island overrun by zombies and other creatures.