The Yo-Kai Deadcool is a parody of the Marvel Comics character Deadpool. Not only are their names, designs, and personalities similar, but three of Deadcool's preset nicknames are direct references to Deadpool. The three identifiable references being "Wade", a reference to Deadpool's real name Wade Wilson, "Ryan", a reference to Ryan Reynolds who portrays Wade Wilson/Deadpool in the live-action films, and "Mr. Cool", which appears to be a reference to a scene from the 2016 film in which the taxi driver Dopinder refers to Deadpool as "Mr. Pool". The last nickname "Rhys" is more ambiguous and does not appear to have a clear origin related to Deadpool.

Additionally, Deadcool's Japanese voice actor, Takehito Koyasu, has voiced Deadpool in other pieces of media.