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On the left hand of the NPC Champagne, a tattoo can be seen of the logo for Frogwares, the game's developer.
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In the scene of Sherlock and Watson on the train departing from Switzerland, a young boy named Hercule approaches Sherlock to help solve his puzzle box and the boy's mother appearing named Madame Poirot. This is a reference to the fictional detective Hercule Poirot by author Agatha Christie, alluding to the young boy being the character.
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The second page of the The Strand newspaper, issue December 2nd, 1894, has a drawing of Inspector Jacques Clouseau from the Pink Panther series. Specifically, the image is taken from the theatrical poster for the 1982 film Trail of the Pink Panther.
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