In order for a movie to break even, it needs to make back at least twice its budget so it can recoup the budget and also cover marketing costs and theater/distributor fees. If it can make 2.5 to 3 times its budget, it is a box office success. Muppets Most Wanted had a budget of $50 million and after recouping its budget it was only able to make back $30.4 million in profit. It did not break even and lost the studio money. The Muppets Christmas Carol had a significantly cheaper budget of $12 million, it was able to break even and made an additional $3.2 million. I can't find any consistent sources on a budget for the other movie to compare, but that is usually how it works for big Hollywood studios.

Despite what's been said about Muppets Most Wanted to point of what can be explained, it says here that it's the third highest grossing film of all time with the Muppet Muppets?: https://www.boxofficemojo.com/franchise/fr2420608773/

It even outgrossed The Muppet Christmas Carol and Muppet Treasure Island, which weren't considered box office failures.